abstract：:The Purkinje cell densities in the cerebellar vermis were determined in 31 male alcoholics and 34 non-alcoholic controls under 70 years of age. In addition, all cases were examined histologically for atrophy of the superior vermis. All analyses were performed independently of each other and on randomized slides. The a...

journal_title：Journal of the neurological sciences

authors： Torvik A,Torp S

更新日期：1986-08-01 00:00:00

abstract：:A procedure for placing a crush lesion in the sciatic and tibial nerve of the rat based on anatomical landmarks is described. These crush lesions are used to study the process of regeneration of peripheral nervous tissue and the beneficial effects of melanocortins on speed and quality of nerve regeneration. A new prec...

journal_title：Journal of the neurological sciences

authors： De Koning P,Brakkee JH,Gispen WH

更新日期：1986-07-01 00:00:00

abstract：:The effects of the specific dopaminergic neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were studied on the kinetics of [3H]mazindol binding to striatal membranes of C57 black mice. This radioligand was used to label dopamine uptake sites and when administered in vivo, MPTP caused an irreversible, no...

journal_title：Journal of the neurological sciences

authors： Donnan GA,Kaczmarczyk SJ,Rowe PJ,Figdor R,Mendelsohn FA

更新日期：1986-06-01 00:00:00

abstract：:Refractoriness of the visual evoked potential to pattern-reversal stimulation has been studied using a light-emitting diode stimulator, the effect on a test P100 of a conditioning pattern reversal being determined for conditioning-test intervals of 20 ms, 50 ms and 100 ms. In 20 normal subjects, the latency of the tes...

journal_title：Journal of the neurological sciences

authors： Skuse NF,Burke D

更新日期：1986-03-01 00:00:00

abstract：:The histochemical ATPase fibre type pattern was examined in muscle biopsy samples obtained from patients with recessive myotonia, paramyotonia and from one patient with dominant myotonia. Absence (less than or equal to 5%) of 2B fibres was a genuine finding in the minority of the cases. In additional cases of recessiv...

journal_title：Journal of the neurological sciences

authors： Heene R,Gabriel RR,Manz F,Schimrigk K

更新日期：1986-03-01 00:00:00

abstract：:A 52-year-old Caucasian male with typical features of myotonic dystrophy (MD) developed a lung abscess and was found to have a mild atypical cyclic neutropenia. Granulocyte function testing revealed a defect in phagocytosis, bactericidal activity and chemotaxis. The defects were less severe at the nadir of the granulo...

journal_title：Journal of the neurological sciences

authors： Friedenberg WR,Marx JJ Jr,Hansotia P,Gottschalk PG

更新日期：1986-03-01 00:00:00

abstract：:Two groups of "mdx" mice, totalling 36 animals of both sexes aged between 8 and 30 weeks, have been studied. In the first group of 10 males and 10 females, 8 males (at 8, 12, 20 and 30 weeks) and 4 females (at 12 and 30 weeks) showed severe limb muscle degeneration and inflammation with prominent regeneration and cent...

journal_title：Journal of the neurological sciences

authors： Bridges LR

更新日期：1986-02-01 00:00:00

abstract：:A low virulence strain of herpes simplex type 1 was microinjected into the hippocampus of BALB/c mice. Intense replication of virus at the inoculum site was followed by spread of viral antigen to the afferent connections of the hippocampus. Surviving animals showed focal damage of limbic structures and specific behavi...

journal_title：Journal of the neurological sciences

authors： McFarland DJ,Sikora E,Hotchin J

更新日期：1986-02-01 00:00:00

abstract：:During postnatal development of the higher vertebrate CNS, large populations of oligodendroglia are generated from precursor cells in a very dependable way. In adult lesioned CNS tissues, local populations of oligodendroglia are replenished by proliferation of this replenishment varies from one species to another and ...

journal_title：Journal of the neurological sciences

authors： Debbage PL

更新日期：1986-02-01 00:00:00

abstract：:In view of the hypothesis that a biochemical abnormality in the childhood forms of neuronal ceroid-lipofuscinosis may lie in the utilization of dolichols in glycoprotein synthesis, we analyzed the oligosaccharide structures of brain glycoproteins in infantile neuronal ceroid-lipofuscinosis (INCL). Lectin affinity chro...

journal_title：Journal of the neurological sciences

authors： Krusius T,Viitala J,Palo J,Maury CP

更新日期：1986-01-01 00:00:00

abstract：:Fatty acid compositions of erythrocyte membrane phospholipids including phosphatidylethanolamine subclasses, blood plasma and mononuclear cells of 8 patients with myotonic dystrophy (MyD) and 8 normal controls were analyzed by high performance liquid chromatography. Slight changes (decreased C18:2 and increased C16:0)...

journal_title：Journal of the neurological sciences

authors： Antoku Y,Sakai T,Goto I,Iwashita H,Kuroiwa Y

更新日期：1985-12-01 00:00:00

abstract：:The present study shows biochemical data on skeletal muscle from 5 patients with Kearns-Sayre syndrome (KSS). Enzyme activities per muscle wet weight in the electron transport system of inner mitochondrial membrane were not significantly different in KSS from those in normal subjects except one patient with long durat...

journal_title：Journal of the neurological sciences

authors： Yorifuji S,Ogasahara S,Takahashi M,Tarui S

更新日期：1985-11-01 00:00:00

abstract：:Concentrations of somatostatin-like immunoreactivity (SLI) were examined in human cerebrospinal fluid (CSF). To validate the assay it was shown that CSF which had been run over a somatostatin immunoaffinity column showed no interference with binding of synthetic standards. Reversed phase HPLC showed that the immunorea...

journal_title：Journal of the neurological sciences

authors： Beal MF,Mazurek MF,Black PM,Martin JB

更新日期：1985-11-01 00:00:00

abstract：:MabQ113 is a monoclonal antibody raised against rat cerebellum which selectively strains Purkinje cells. Likewise, in mabQ113-immunoperoxidase stained sections of human cerebellum, deposits of reaction product are found only in the Purkinje cells. The dendritic arborizations, cell body, and axonal processes are immuno...

journal_title：Journal of the neurological sciences

authors： Plioplys AV,Thibault J,Hawkes R

更新日期：1985-10-01 00:00:00

abstract：:Areas of persistent demyelination were created in the dorsal columns of the cat spinal cord by injecting ethidium bromide into white matter which had previously been exposed to 40 Grays of X-irradiation. In the centre of such lesions demyelinated axons occurred in a glial-free area while axons next to normal tissue we...

journal_title：Journal of the neurological sciences

authors： Blakemore WF,Crang AJ

更新日期：1985-09-01 00:00:00

abstract：:Somatosensory evoked potentials (SEPs) were recorded in a group of 18 patients with dystrophia myotonica and in 28 control subjects after stimulating the right and left posterior tibial (SEP-PT) and sural (SEP-S) nerves at the ankles. Recording electrodes were placed in the popliteal fossae, overlying the L3 spinal ve...

journal_title：Journal of the neurological sciences

authors： Bartel P,Lotz B,Robinson E,Van der Meyden C

更新日期：1985-08-01 00:00:00

abstract：:The frequency of senile plaques and neurofibrillary tangles and the number of pyramidal neurones and the volume of their nucleolus were measured in temporal cortex (middle temporal gyrus) and hippocampus (area h1) of 32 patients with Alzheimer's disease. Plaques and tangles were greatly increased in frequency in these...

journal_title：Journal of the neurological sciences

authors： Mann DM,Yates PO,Marcyniuk B

更新日期：1985-07-01 00:00:00

abstract：:Low fluidity was observed in the erythrocyte membranes of familial chorea-acanthocytosis by spin labeling with 12NS. The high content of the saturated fatty acids support the finding of low fluidity. Other lipid contents (cholesterol and phospholipids) and the cholesterol/phospholipid ratio were within normal ranges. ...

journal_title：Journal of the neurological sciences

authors： Oshima M,Osawa Y,Asano K,Saito T

更新日期：1985-05-01 00:00:00

abstract：:Brain myelin was studied in genetically obese (ob/ob) mice and compared with that of normal (+/+) mice from the same strain. The brain from obese mice had a significantly lower amount of myelin, and marked changes in the fatty acid composition of myelin were observed. In contrast, the myelin cholesterol: phospholipid:...

journal_title：Journal of the neurological sciences

authors： Sena A,Sarliève LL,Rebel G

更新日期：1985-05-01 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconate dehydrogenase (6PGDH) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activities were assayed in superficial pectoral muscles of hereditary dystrophic chickens, 1 week, 2 weeks, 4 weeks and 4 months after hatching. In control chickens, activities of G6...

journal_title：Journal of the neurological sciences

authors： Mizuno Y

更新日期：1985-04-01 00:00:00

abstract：:Using EMG equipment with time locked recording and standard averaging facilities we were able to record a previously poorly defined skin potential. The potential, termed by us the peripheral autonomic surface potential (PASP), was recorded from the palmar surface of the hand and the plantar surface of the foot in 30 n...

journal_title：Journal of the neurological sciences

authors： Knezevic W,Bajada S

更新日期：1985-02-01 00:00:00

abstract：:A blink reflex consists of an early unilateral component, R1, and a late bilateral component, R2. During an acute phase of hemispheric cerebrovascular accident, R1 and R2 were abnormal in 30 and 50 of 66 patients, respectively. Paired stimuli usually corrected R1 but not R2, which was profoundly suppressed. The discre...

journal_title：Journal of the neurological sciences

authors： Kimura J,Wilkinson JT,Damasio H,Adams HR Jr,Shivapour E,Yamada T

更新日期：1985-01-01 00:00:00

abstract：:A 31/2-year-old girl presented with frequent falls. She had an unsteady gait, delayed behavioural development absent tendon reflexes and in the legs decreased strength tone and equivocal plantar responses. She then developed ataxia, nystagmus, choreoathetosis, cranial nerve palsies, diminished strength and tone in the...

journal_title：Journal of the neurological sciences

authors： Patel H,Norman MG,Perry TL,Berry KE

更新日期：1985-01-01 00:00:00

abstract：:We performed a population based survival analysis of all incident cases (220) of motor neuron disease (MND) in the province of Turin, Italy, during the period 1966-1980. 175 cases were diagnosed as amyotrophic lateral sclerosis (ALS), 43 as progressive muscular atrophy (PMA) and 2 as progressive bulbar palsy (PBP). Th...

journal_title：Journal of the neurological sciences

authors： Mortara P,Chiò A,Rosso MG,Leone M,Schiffer D

更新日期：1984-11-01 00:00:00

abstract：:Adoptive transfer of experimental allergic encephalomyelitis (EAE) was achieved in Lewis rats using spleen cells incubated in vitro with various lectins. When stimulated with concanavalin A (Con A), its derivative succinyl-Con A, Lens culinaris or Pisum sativum agglutinin, spleen cells obtained from rats immunized wit...

journal_title：Journal of the neurological sciences

authors： Takenaka A,Kaneko K,Mori R,Itoyama Y

更新日期：1984-11-01 00:00:00

abstract：:Iodized oil was administered as a single intramuscular injection to pregnant iodine-deficient ewes at 100 days gestation and the subsequent growth of their fetuses compared with that of fetuses of severely iodine-deficient ewes and of iodine-replete ewes, all of which were fed the same low-iodine diet. The administere...

journal_title：Journal of the neurological sciences

authors： Potter BJ,Mano MT,Belling GB,Martin DM,Cragg BG,Chavadej J,Hetzel BS

更新日期：1984-10-01 00:00:00

abstract：:Chronic relapsing experimental allergic encephalomyelitis has been induced in juvenile strain 13 guinea pigs with isologous spinal cord in Freund's complete adjuvant. Retention of antigen at the injection site and in the draining lymph nodes was studied by immunocytochemical staining with antiserum to myelin basic pro...

journal_title：Journal of the neurological sciences

authors： Tabira T,Itoyama Y,Kuroiwa Y

更新日期：1984-10-01 00:00:00

abstract：:Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC to induce central nervous system demyelination is complement-dependent, and demyelinating activity is present in the immunoglobulin fraction of an...

journal_title：Journal of the neurological sciences

authors： Sergott RC,Brown MJ,Silberberg DH,Lisak RP

更新日期：1984-06-01 00:00:00

abstract：:In rabbits subjected to bicuculline (BC)- or pentylenetetrazole (PTZ)-seizures of 3 or 20 min duration or to adrenaline-induced hypertension, specific gravity (SG) was measured bilaterally in 15 regional brain areas in order to detect possible associations between the regionally limited blood-brain barrier openings du...

journal_title：Journal of the neurological sciences

authors： Nitsch C,Fujiwara K,Kuroiwa T,Klatzo I

更新日期：1984-05-01 00:00:00

abstract：:Five males in one kindred suffered from intermittent ataxia and one female may have been more mildly affected. The pattern of inheritance strongly suggests X-linkage. Cerebral pathology in one case had some features of Leigh's disease. A defect in pyruvate metabolism was found in two cases. Acetazolamide gave a tempor...

journal_title：Journal of the neurological sciences

authors： Livingstone IR,Gardner-Medwin D,Pennington RJ

更新日期：1984-04-01 00:00:00

abstract：:Over the last 30 years glucose intolerance has been reported in a significant percentage of patients with amyotrophic lateral sclerosis (ALS). Currently, a controversy exists in determining whether the carbohydrate abnormality is disease-specific or secondary to decreased glucose utilization due to muscle atrophy. A r...

journal_title：Journal of the neurological sciences

authors： Reyes ET,Perurena OH,Festoff BW,Jorgensen R,Moore WV

更新日期：1984-03-01 00:00:00

abstract：:The acute effect of a single intraperitoneal dose of alcohol (2 g kg-1 body weight) was studied in normally fed rats anaesthetised with sodium pentabarbitone . Rapidly achieved high blood alcohol levels were accompanied by an equally rapid but transient 4-fold increase in the total creatine kinase (CK) activity in the...

journal_title：Journal of the neurological sciences

authors： Spargo E

更新日期：1984-03-01 00:00:00

abstract：:In boys with Duchenne muscular dystrophy (DMD) plasma myoglobin levels remained approximately constant with age while creatine kinase (CK) activity progressively decreased. For carrier detection, plasma myoglobin level was found to be less reliable than CK activity. The myoglobin level was raised only in some of those...

journal_title：Journal of the neurological sciences

authors： Edwards RJ,Rodeck CH,Watts DC

更新日期：1984-02-01 00:00:00

abstract：:The clinical, genetic and electrophysiological study of 3 patients with an association of a neuronal form of Charcot-Marie-Tooth Disease (CMTD) with a syndrome of continuous motor unit activity (CMUA) are reported, with light and electron microscopy of muscle and sural nerve biopsies in 2 patients. The unusual clinica...

journal_title：Journal of the neurological sciences

authors： Vasilescu C,Alexianu M,Dan A

更新日期：1984-01-01 00:00:00

abstract：:The neuropathological findings in two siblings with Menkes' disease were compared with representative material obtained from lambs suffering from swayback (enzootic ataxia). The aim of the study was to demonstrate the similarity of lesions in a genetic and a nutritional form of copper deficiency in support of the view...

journal_title：Journal of the neurological sciences

authors： Tan N,Urich H

更新日期：1983-12-01 00:00:00

abstract：:The muscle provocation test (MPT: 40 min of strenuous exercise on a bicycle ergometer) is a sensitive method for the detection of carriers of Duchenne muscular dystrophy. The diagnostic applicability of MPT for carrier detection in X-linked Becker muscular dystrophy is demonstrated. Obligate carriers with mean creatin...

journal_title：Journal of the neurological sciences

authors： Herrmann FH,Spiegler AW

更新日期：1983-12-01 00:00:00

abstract：:The present study used the nerve pathology, studied by quantitative light microscopy, as the sole basis for classification of peroneal muscular atrophy (PMA). The findings in biopsies of superficial peroneal nerves of 20 patients were compared with normal values obtained from 8 controls. Three homogeneous groups compr...

journal_title：Journal of the neurological sciences

authors： Gherardi R,Bouché P,Escourolle R,Hauw JJ

更新日期：1983-10-01 00:00:00

abstract：:The purpose of the investigation was to elucidate the repeatedly discussed relationship between chronic lead intoxication and ALS. The following mean lead concentrations were determined in 9 patients with ALS: 8.65 +/- 3,91 micrograms/100 ml in the blood, 0.97 +/- 0.78 microgram/100 ml in the plasma, 19.15 +/- 5.0 mic...

journal_title：Journal of the neurological sciences

authors： Stober T,Stelte W,Kunze K

更新日期：1983-09-01 00:00:00

abstract：:Immunologically pure IgG was isolated from serum of multiple sclerosis (MS) patients and normal controls. The F(ab)2 moiety of IgG was then isolated by salting out between 12.5 and 19.0% Na2SO4 of the pepsin digest of IgG. The ability of the 131I-labelled F(ab)2 to bind to subcellular brain fractions (nuclei, synaptos...

journal_title：Journal of the neurological sciences

authors： Clausen J

更新日期：1983-08-01 00:00:00

abstract：:The findings are reported of various CSF abnormalities, including IgG indices and oligoclonal IgG, in 160 patients with multiple sclerosis of differing diagnostic certainty and 146 patients with other neurological disorders. An abnormal IgG index, defined as the ratio of IgG/albumin in CSF to that in serum, has been f...

journal_title：Journal of the neurological sciences

authors： Perkin GD,Sethi K,Muller BR

更新日期：1983-08-01 00:00:00